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Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
(Wiley Blackwell Publishing, Inc, 2020-01-13)
Essential hypertension is considered to be a result of the interaction between genetic and environmental factors, including perinatal factors. Different advantageous perinatal factors proved to have beneficial long-lasting ...
Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children
(Nature Publishing Group, 2003-12)
Background. Obstructive nephropathy leads to tubulointerstitial fibrosis and loss of renal function. Nitric oxide has been shown to have antifibrotic properties. We examined nitric oxide synthase (NOS) activity and expression ...
Hypothyroidism: Age-related influence on cardiovascular nitric oxide system in rats
(W B Saunders Co-Elsevier Inc, 2012-09)
This study investigates whether changes in nitric oxide (NO) production participate in the cardiovascular manifestations of hypothyroidism and whether these changes are age-related. Sprague-Dawley rats aged 2 and 18 months ...
Alteration of syncytiotrophoblast mitochondria function and endothelial nitric oxide synthase expression in the placenta of rural residents
(Pergamon-Elsevier Science Ltd, 2016-06)
The impact of environmental organophosphate (OP) pesticide exposure on respiratory complexes, enzymatic antioxidant defense activities, and oxidative damage markers in the syncytiotrophoblast and cytotrophoblast mitochondria ...
Adverse effects of tempol on hidrosaline balance in rats with acute sodium overload
(Informa Healthcare, 2016-11)
We studied the effects of tempol, an oxygen radical scavenger, on hydrosaline balance in rats with acute sodium overload. Male rats with free access to water were injected with isotonic (control group) or hypertonic saline ...
Expression of Nitric Oxide Synthases in Rat Adrenal Zona Fasciculata Cells
(Endocrine Society, 2002-04)
Nitric oxide (NO) synthase (NOS) expression was analyzed in rat adrenal zona fasciculata. Both neuronal NOS and endothelial NOS mRNAs were detected by RT-PCR, immunohistochemistry, and immunoblot analysis. The biochemical ...
Nitric oxide synthase and oxidative-nitrosative stress play a key role in placental infection by Trypanosoma cruzi
(Wiley Blackwell Publishing, Inc, 2018-07)
Problem: The innate immune response of the placenta may participate in the congenital transmission of Chagas disease through releasing reactive oxygen and nitrogen intermediates. Method of study: Placental explants were ...
Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats
(Karger, 2004-12)
There is evidence that α-melanocyte-stimulating hormone (α-MSH) has immunomodulatory and anti-inflammatory actions within the brain. In this study, we tested whether these actions are due to inhibition of the synthesis of ...
Lysophosphatidic acid-triggered pathways promote the acquisition of trophoblast endovascular phenotype in vitro
(Wiley-liss, Div John Wiley & Sons Inc, 2018-01)
Successful implantation and placentation requires that extravillous cytotrophoblast acquires an endovascular phenotype and remodels uterine spiral arteries. Defects in this mechanism correlate with severe obstetric ...
Interleukin-1ß regulates nitric oxide production and gamma-glutamyltranspeptidase activity in Sertoli cells
(American Society of Andrology, 2000-12)
Several cytokines have been involved in the regulation of Sertoli cell function. Further investigations are required to elucidate the role of interleukin-1beta (IL1beta) in Sertoli cell physiology. Twenty-day-old rat ...